Such novel psychedelics include the 2C-series and its structural analogs, including N-Benzylphenethylamines (NBOMes) (Tracy et al., 2017). 2C-series, also called 2C-drugs/compounds, are a related group of substances with presumably psychedelic and psychostimulant properties. All of them are phenylethylamine https://rehabliving.net/awareness-of-alcohols-link-to-cancer-lagging-nci/ derivatives structurally close to mescaline with methoxy substitutions at the 2 and 5 positions derived from the two carbon molecules between the benzene ring and the amino group. 2,5-dimethoxy-4-bromophenethylamine (2C-B, Nexus) is one of the oldest and best known 2C-type drugs.
-B Long-Term Side Effects
- Because the results showed only marginal statistically significant results for interactions between dose and gender, dose or gender, the analysis was rejected (nine variables showed significant results for a total number of 198 comparisons).
- Vaporizing the drug instead of eating it doesn’t seem to have any benefits.
- 2C-B has also been shown to have some action at the alpha-adrenergic receptors [3].
- Having a sober trip sitter is also a great way to reduce harm and keep you feeling safe and secure especially on doses over 15 mg or for your first time with the novel substance.
- In a similar manner to other NSPs and some psychedelics, the human pharmacokinetics of 2C-B has not yet been fully resolved.
Some users mix MDMA and 2C-B, known as a “nexus flip.” The purpose of consuming a nexus flip is to extend the euphoric feeling of MDMA. Users typically ingest 2C-B as they begin to come down from the MDMA. About an hour later, one reenters the experience with the enhanced visuals of the psychedelic. Biochemists use this research chemical to map out type 2A serotonin receptors in the brain. Though discovered in 2003, NBOMe has no history of human use prior to 2010 when it first became available over the internet.
Why choose 2C-B over other psychedelics?
When various government regulators started banning 2C-B, they did so by banning the entire 2C-x family — as defined by the chemical structure above. 2C-B isn’t used medically because of its current standing as a Schedule I substance in the United States. It’s classified under equivalent filings in other countries, such as the United Kingdom, Canada, Australia, Germany, and Europe.
-B Addiction: Symptoms, Signs & Treatment
Additionally, results show that the self-administration of 2C-B at the narrow dose range studied (10–20 mg) in healthy experienced users in a non-medical setting is relatively safe (González et al., 2015). In contrast to our previous publication (González et al., 2015), that focused on the effects of 20 mg on emotions, the present study included a more intensive evaluation of vital signs, and a more complete collection of oral fluid. These evaluations provided a picture of the time-course of the effects of 2C-B on physiological measures and permitted a comparison between the time-course of the effects and the concentrations of 2C-B in oral fluid. Again, our findings concur with the limited number of cases reporting severe acute toxicity related to 2C-B use. While a number of fatalities have been linked to other substances in the 2C-drug group none have been attributed to 2C-B alone. Results were similar to those described in previous works and surveys, all symptoms were resolved by 6 h (Caudevilla-Gálligo et al., 2012; Nugteren-van Lonkhuyzen et al., 2015).
Drug Information
This includes alcohol, cigarettes, and prescription medications. The main risk of this compound is adulteration (mixing or swapping other substances into 2C-B tablets or powder). One of the main benefits of 2C-B over MDMA is that users usually don’t experience difficulty falling asleep after the experience. With LSD, the euphoria needs to be earned through experience and mindset. It doesn’t have an inherent euphoric quality to it, so those without the right mindset may not feel any euphoria whatsoever. The intensity of effects from 2CB increases steadily along with the dose.
Snorting 2C-B brings on its effects much faster and can prolong the experience for up to 12 hours. There was a tragic story in 2012 about an actor, Johnny Lewis, having had a psychotic episode after taking a 2C drug that resulted in his suicide. The family became known as “Smiles,” which is a name that seems to have been invented by the media.
In some Latin American countries as Colombia, also 2C-B is considered an NPS due to its recent presence in the market (Colombia National Study of Psychoactive Substance Consumption, 2013). Many psychonauts recommend starting with a light dose but this isn’t necessarily the best way to go.If you start at lower doses, your ego will learn how to control the psychedelic states. Because of that, it’ll be harder to let go once you move to higher doses and this can easily lead to bad trips.You will also not get as many benefits from the drug as if you were to start with higher doses. It’s been shown that mystical experiences can deeply change your identity and the higher the dose you take, the more intense they will be. Do not, however, start with a strong dose if you don’t have a trip sitter nearby.High doses can easily cause you to reach a breakthrough where you lose sense of the physical world.
Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. 2C-B use also increases dopamine in the nucleus accumbens of rats. The nucleus accumbens is a brain region in the reward pathway that is involved in responses to rewarding stimuli.
There is no evidence that they would be physically harmful.Many of these chemicals are completely legal as long as you buy them for “chemical research” purposes. You cannot consume them legally but whether or not anyone cares is a different story. Therefore, there is virtually no way to know what your trip will feel like.The only way to truly know what 2C-B feels like is to https://sober-house.org/understanding-alcohol-and-anger-s-connection/ take 2C-B.2C-B will most likely give you a pleasant experience. Bad trips can happen but you can prevent them by following the tips below. 2C-B feels like a cross between MDMA and LSD but it doesn’t feel like a “candy flip” which is taking LSD and MDMA at the same time. In lower doses, 2C-B is more empathogenic–inducing feelings of connectedness, empathy, and sociability.
The increase in dopamine suggests that 2C-B may be potentially addictive. The sale of 2C-B is unregulated, and the drug may be tainted with other substances or be a different drug altogether. The underground psychiatry community originally advocated for the drug as a facilitator or aid in psychotherapy, but these claims of its effectiveness in therapy remain unproven.
The effects will be much stronger and appear much more quickly. Take a lower dose than you normally would and give it time to take effect. In smaller doses these effects are limited, but higher doses of 2C-B produce intense changes in sensory perception. Users often report the textures of heroin feelings of introspection, ego-dissolution, and a stronger sense of empathy and connection with others. It’s not uncommon for people using 2C-B to come to some sort of “realization” about their life. This realization may remain after the trip, but it may also be forgotten.
You can never trust what’s inside your pills or powders unless you test it first. And even with testing, you can’t be 100% sure it’s free from harmful chemicals. The more 2C-B you take, the further the experience diverges from MDMA. High doses are very psychedelic and can make being at public events very uncomfortable — unlike MDMA. 2C-B is more stimulating than mescaline and has much less “headspace.” Headspace refers to the introspective and existential thoughts that accompany the psychedelic experience.